Antimicrobial and Antioxidant Properties of Photodegraded Amorphous Curcumin on Silica Nanoparticles

This work utilizes the concept of curcumin amorphization to improve drawbacks currently found if it is used as a pharmaceutical ingredient, such as low solubility, limited bioavailability, and absorption, by anchoring it with silica nanoparticles (SiO2NP). Curcumin loading was determined following kinetic and adsorption parameters, resulting in more than 70% of the curcumin being loaded onto nanoparticles after 180 min. The adjusted data resulted in a Langmuir and BET best-fit with a coefficient relating to favorable adsorption and a multilayer mechanism. With a reduction of more than 70% of the particle area after curcumin loading, it increased the SiO2NP size. Due to curcumin, FTIR data presented a free unbounded vibration of SiO2NP, disappearing in favor of a chemical reaction.